4-(Trifluoromethyl)benzenemethanol → HCID 22253138, compound

HRID 1182007Notes

Reaction equation

HRID 1182007 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][C:6]([CH2:7][OH:8])=[CH:5][CH:4]=1.[ClH:13].[NH2:14][CH2:15][C:16](=[O:22])[CH2:17][CH2:18][C:19](O)=[O:20]>>[ClH:13].[NH2:14][CH2:15][C:16](=[O:22])[CH2:17][CH2:18][C:19]([O:8][CH2:7][C:6]1[CH:9]=[CH:10][C:3]([C:2]([F:11])([F:12])[F:1])=[CH:4][CH:5]=1)=[O:20]

Participants

3

Reactant 2

HCID 676844-(Trifluoromethyl)benzenemethanolHCID 123608Aminolevulinic Acid Hydrochloride

Product 1

HCID 22253138HCID 22253138, compound

Procedure

From 4-(trifluoromethyl)benzyl alcohol (4.9 g; 28 mmol) and 5-amino-4-oxopentanoic acid hydrochloride (1.0 g; 6.0 mmol). The reaction was complete after 2 h. The yield was 1.24 g (64%).

Sources & evidence

ORD record
ord-248eac2cf3a349198dcc6cf1c479e6bc
Source dataset
uspto-grants-2007_10
Patent number
US07287646B2

Reaction notes

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