HuagongsheHuagongshe Chemistry Print Report · For research reference only
H-Gln-OtBu hydrochloride → N-(Toluene-4-sulfonyl)-L-prolyl-L-glutamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | H-Gln-OtBu hydrochloride | HCID 15602445 | — |
| Reactant | N-tosyl-(s)-proline monohydrate | HCID 69463844 | — |
| Product | N-(Toluene-4-sulfonyl)-L-prolyl-L-glutamine | HCID 53697337 | — |
Reaction Steps
N-(Toluene-4-sulfonyl)-L-proline hydrate was coupled to L-glutamine tert-butyl ester hydrochloride using the procedure described in Method 3. The title compound, prepared via cleavage of the tert-butyl ester using trifluoroacetic acid in CH2Cl2, was recovered as a solid, mp=45-55° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07288526B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-2e4228c1db7d40ec8b8bc26f0d0cae29 |
| Source note | uspto-grants-2007_10 |