HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → N-(Toluene-4-sulfonyl)-L-prolyl-Nepsilon-(carbobenzyloxy)-L-lysine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | H-Lys(Z)-OMe HCl | HCID 12935371 | — |
| Reactant | N-tosyl-(s)-proline monohydrate | HCID 69463844 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | N-(Toluene-4-sulfonyl)-L-prolyl-Nepsilon-(carbobenzyloxy)-L-lysine | HCID 53968365 | — |
Reaction Steps
N-(Toluene-4-sulfonyl)-L-proline hydrate was coupled to Nε-Cbz-L-lysine methyl ester hydrochloride using the procedure described in Method 3. The title compound was prepared via hydrolysis of the methyl ester using LiOH in THF/water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07288526B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-2e3d2dbb471343069139593e528e2bd8 |
| Source note | uspto-grants-2007_10 |