Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1182061생성일: 2026년 10월 26일
Triethylamine → 5-[5-Bromo-4-(1-ethyl-2-oxo-propylsulfanyl)-pyrimidin-2-ylamino]-pyridine-2-sulfonic acid amide
https://huagongshe.com/reaction/1182061
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-Mercapto-2-pentanone | HCID 62237 | — |
| 반응물 | 5-(5-bromo-4-chloro-pyrimidin-2-ylamino)-pyridine-2-sulfonic Acid Amide | HCID 58981865 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-[5-Bromo-4-(1-ethyl-2-oxo-propylsulfanyl)-pyrimidin-2-ylamino]-pyridine-2-sulfonic acid amide | HCID 58981835 | — |
반응 단계
73 mg (0.2 mmol) of 5-(5-bromo-4-chloro-pyrimidin-2-ylamino)-pyridine-2-sulfonic acid amide and 32 mg (0.27 mmol) of 3-mercapto-2-pentanone are dissolved in 4 ml of DMF p.a. After 0.038 ml (0.27 mmol) of triethylamine is added, it is allowed to stir for 2 hours at room temperature and for 3 hours at 50° C. After concentration by evaporation, it is flashed with dichloromethane/MeOH (9:1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07288547B2 |
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| 출처 데이터셋 | uspto-grants-2007_10 |
|---|
| ORD ID | ord-3c4bd87c289f423588e0c9618dde772d |
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| 출처 메모 | uspto-grants-2007_10 |
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