Potassium Iodide → Ethyl 4-(diphenylmethoxy)-1-piperidinebutanoate

Participants

Reaction Steps

To 28 mL of methyl isobutyl keton (MIBK) was added 4-(benzhydryloxy)piperidine (1.5 g), NaHCO3 (1.42 g), potassium iodide (catalyst), and ethyl-4-chlorobutyrate (1.2 mL). The resulting mixture was refluxed for 4 hrs. The resulting mixture was cooled, and concentrated under reduced pressure. The resultant solution was then extracted by using water and chloroform. An organic solution layer was dehydrated over magnesium sulfate, filtered, and concentrated under reduced pressure. The column chromatography was performed thereon, thereby obtaining crude yellowish liquid product (1.41 g, 66% yield) of the title.

Provenance & Evidence