Potassium Iodide → HCID 10335262, compound

Participants

Reaction Steps

To 12 mL of N,N-dimethylformamide was added 4-(benzyloxy)piperidine (0.8 g), sodium bicarbonate (1.05 g), potassium iodide (used as a catalyst), ethyl-4-chlorobutyrate (0.88 mL). The resulting mixture was refluxed for 4 hrs. The resulting mixture was cooled, and concentrated under reduced pressure. The resultant mixture was then extracted by using water and chloroform. An organic solution layer was dehydrated over magnesium sulfate, filtered, and concentrated under reduced pressure. The column chromatography was performed thereon, thereby obtaining crude yellowish liquid product (1.05 g, 82% yield) of the title.

Provenance & Evidence