Triethylamine → HCID 131726650, compound

Participants

Reaction Steps

A solution of 4-fluorobenzoyl-azetidine hydrochloride (0.192 g, 0.892 mmol), triethylamine (0.252 ml, 3.24 mmol) and [(S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-propyl]-carbamic acid tert-butyl ester (0.448 g, 0.811 mmol) in dimethylformamide (3 ml) is stirred at ambient temperature for 18 hours, then partitioned between ethylacetate and water. The ethylacetate phase is dried over MgSO4 and evaporated. The crude product is purified by flash silica chromatography (elution with a 1:99 methanol/dichloromethane) to afford {(S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-[3-(4-fluoro-benzoyl)-azetidin-1-yl]-propyl}carbamic acid tert-butyl ester. [MH]+ 605.2.

Provenance & Evidence