反应详情

A solution of {(R)-3-[3-(4-chloro-phenoxy)-azetidin-1-yl]-1-methyl-propyl}-carbamic acid tert-butyl ester (0.019 mg, 0.053 mmol) in DCM (1 ml) is treated with trifluoroacetic acid (0.042 ml) and stirred at room temperature overnight. The solvent is evaporated and the residue partition between DCM and 1M sodium hydroxide solution. The aqueous phase is extracted with more DCM (×3) and the combined organic phases washed with brine, dried over magnesium sulphate and evaporated to afford (R)-3-[3-(4-chloro-phenoxy)-azetidin-1-yl]-1-methyl-propylamine. [M+H] 255.22

1. customThe solvent is evaporated
2. customthe residue partition between DCM and 1M sodium hydroxide solution
3. extractionThe aqueous phase is extracted with more DCM (×3)
4. washthe combined organic phases washed with brine
5. dry with materialdried over magnesium sulphate
6. customevaporated