3-Cyclobutyl-3-oxopropanenitrile → 3-Cyclobutyl-1-methyl-1H-pyrazol-5-amine

HRID 1182110Notes

Reaction equation

HRID 1182110 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([NH2:9])[N:6]([CH3:8])[N:7]=1)[CH3:2].[CH:10]1(C(=O)CC#N)CC[CH2:11]1>>[CH:1]1([C:3]2[CH:4]=[C:5]([NH2:9])[N:6]([CH3:8])[N:7]=2)[CH2:11][CH2:10][CH2:2]1

Participants

3

Reactant 2

HCID 138611153-Cyclobutyl-3-oxopropanenitrileHCID 151357823-ethyl-1-methyl-1H-pyrazol-5-amine

Product 1

HCID 133248283-Cyclobutyl-1-methyl-1H-pyrazol-5-amine

Procedure

This is synthesized in an analogous manner to 5-ethyl-2-methyl-2H-pyrazol-3-ylamine except using 3-cyclobutyl-3-oxopropionitrile instead of 3-oxo-pentanenitrile.

Sources & evidence

ORD record
ord-14a105b28d674b9683e9aac9515bbecb
Source dataset
uspto-grants-2007_10
Patent number
US07288537B2

Reaction notes

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