3,4-Difluorophenyl isocyanate → HCID 10126413, compound

Participants

Reaction Steps

A solution of 3-[3-(4-fluoro-phenoxy)-azetidin-1-yl]-propylamine (0.04 g, 0.178 mmol) and 3,4-difluorophenylisocyanate (0.020 ml, 0.178 mmol) in dichloromethane (1 ml) is stirred at room temperature for 5 hours. The solvent is evaporated and the crude product purified by flash silica chromatography (elution gradient a 3:97 to 5:95 methanol/dichloromethane) to afford 1-(3,4-difluoro-phenyl)-3-{3-[3-(4-fluoro-phenoxy)-azetidin-1-yl]-propyl}-urea. [MH]+ 379.9.

Provenance & Evidence