3-Methoxyphenyl isocyanate → HCID 10172577, compound

Participants

Reaction Steps

A solution of 3-[3-(4-fluoro-phenoxy)-azetidin-1-yl]-propylamine (0.07 g, 0.31 mmol) and 1-isocyanato-3-methoxy-benzene (0.041 g, 0.31 mmol) in dioxane (15 ml) is heated to 100° C. for 3 hours. The reaction mixture is evaporated and the crude product purified by flash silica chromatography (elution with a 1:9 methanol/dichloromethane) to afford 1-{3-[3-(4-fluoro-phenoxy)-azetidin-1-yl]-propyl}-3-(3methoxy-phenyl)-urea. [MH]+ 374.0.

Provenance & Evidence