HCID 10288269, compound → HCID 10173950, compound

HRID 1182139Notes

Reaction equation

HRID 1182139 reaction equation
C([SiH2][O:6][C:7](C1C=CC=CC=1)(C1C=CC=CC=1)[C@@H:8]([N:23](C)[C:24]([NH:26][C:27]1[CH:32]=[C:31]([O:33][CH3:34])[CH:30]=[C:29]([O:35][CH3:36])[CH:28]=1)=[O:25])[CH2:9][CH2:10][N:11]1[CH2:14][CH:13]([O:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)[CH2:12]1)(C)(C)C.[CH3:50]OC1C=C(NC(N[C@H](CO)CCN2CC(C(=O)C3C=CC(F)=CC=3)C2)=O)C=C(OC)C=1>>[Cl:22][C:19]1[CH:20]=[CH:21][C:16]([O:15][CH:13]2[CH2:12][N:11]([CH2:10][CH2:9][C@H:8]([NH:23][C:24](=[O:25])[N:26]([C:27]3[CH:32]=[C:31]([O:33][CH3:34])[CH:30]=[C:29]([O:35][CH3:36])[CH:28]=3)[CH3:50])[CH2:7][OH:6])[CH2:14]2)=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 10288269HCID 10288269, compoundHCID 131726654HCID 131726654, compound

Product 1

HCID 10173950HCID 10173950, compound

Procedure

1-{(S)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-3-[3-(4-chloro-phenoxy)-azetidin-1-yl]-propyl}-3-(3,5-dimethoxy-phenyl)-1-methyl-urea is deprotected in the same manner as 1-(3,5-Dimethoxy-phenyl)-3-{(S)-3-[3-(4-fluoro-benzoyl)-azetidin-1-yl]-1-hydroxymethyl-propyl}-urea in Example 34 to afford 3-{(S)-3-[3-(4-Chloro-phenoxy)-azetidin-1-yl]-1-hydroxymethyl-propyl}-1-(3,5-dimethoxy-phenyl)-1-methyl-urea. [M+H] 463.5

Sources & evidence

ORD record
ord-a4317b1b5b934b5b848af77f18ca2cef
Source dataset
uspto-grants-2007_10
Patent number
US07288537B2

Reaction notes

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