HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isocyanate → 1-{(S)-3-[3-(4-Chloro-phenoxy)-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(3-methoxy-phenyl)-thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isocyanate | HCID 105034 | — |
| Reactant | 1-[(S)-3-[3-(4-chloro-phenoxy)-azetidin-1-yl]-1-hydroxymethyl-propyl)-3-(3,5-dimethoxy-phenyl)-urea | HCID 10238445 | — |
| Reactant | HCID 178418790 | HCID 178418790 | — |
| Product | 1-{(S)-3-[3-(4-Chloro-phenoxy)-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(3-methoxy-phenyl)-thiourea | HCID 86600853 | — |
Reaction Steps
This compound is prepared in a manner analogous to that used to prepare 1-{(S)-3-[3-(4-Chloro-phenoxy)-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(3,5-dimethoxy-phenyl)-urea in Example 26 except in the final step the isocyanate is replaced with the appropriate isothiocyanate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07288537B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-c163623625b24219a69faa660857763b |
| Source note | uspto-grants-2007_10 |