1-{(S)-3-[3-(4-Chloro-phenoxy)-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(5-ethyl-2-methyl-2H-pyrazol-3-yl)-urea → 1-{(S)-3-[3-(3,4-dichloro-phenoxy)-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(5-ethyl-2-methyl-2H-pyrazol-3-yl)-urea

HRID 1182141Notes

Reaction equation

HRID 1182141 reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([O:6][CH:7]2[CH2:10][N:9]([CH2:11][CH2:12][C@H:13]([NH:16][C:17]([NH:19][C:20]3[N:21]([CH3:27])[N:22]=[C:23]([CH2:25][CH3:26])[CH:24]=3)=[O:18])[CH2:14][OH:15])[CH2:8]2)=[CH:4][CH:3]=1.Cl.N[C@@H](CCN1CC(OC2C=CC([Cl:48])=C(Cl)C=2)C1)CO>>[Cl:48][C:29]1[CH:28]=[C:5]([CH:4]=[CH:3][C:2]=1[Cl:1])[O:6][CH:7]1[CH2:8][N:9]([CH2:11][CH2:12][C@H:13]([NH:16][C:17]([NH:19][C:20]2[N:21]([CH3:27])[N:22]=[C:23]([CH2:25][CH3:26])[CH:24]=2)=[O:18])[CH2:14][OH:15])[CH2:10]1

Participants

3

Reactant 2

HCID 102878861-{(S)-3-[3-(4-Chloro-phenoxy)-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(5-ethyl-2-methyl-2H-pyrazol-3-yl)-ureaHCID 69411346(S)-2-amino-4-[3-(3,4-dichloro-phenoxy)-azetidin-1-yl]-butan-1-ol hydrochloride

Product 1

HCID 698478531-{(S)-3-[3-(3,4-dichloro-phenoxy)-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(5-ethyl-2-methyl-2H-pyrazol-3-yl)-urea

Procedure

This compound is prepared in a manner analogous to that used to prepare 1-{(S)-3-[3-(4-chloro-phenoxy)-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(5-ethyl-2-methyl-2H-pyrazol-3-yl)-urea in Example 88 except using (S)-2-amino-4-[3-(3,4-dichloro-phenoxy)-azetidin-1-yl]-butan-1-ol hydrochloride in place of (S)-2-amino-4-[3-(4-chloro-phenoxy)-azetidin-1-yl]-butan-1-ol hydrochloride.

Workup

  1. customThis compound is prepared in a manner analogous to

Sources & evidence

ORD record
ord-989baf9492e9441196f8d305559bd2ec
Source dataset
uspto-grants-2007_10
Patent number
US07288537B2

Reaction notes

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