HCID 12256156, compound → HCID 69846752, compound

HRID 1182142Notes

Reaction equation

HRID 1182142 reaction equation
[CH2:1]([C:3]1[S:7][C:6]([NH:8][C:9]([NH2:11])=[O:10])=[N:5][N:4]=1)[CH3:2].Cl.N[C@@H:14]([CH2:17][CH2:18][N:19]1[CH2:22][CH:21]([O:23][C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[C:26]([F:31])[CH:25]=2)[CH2:20]1)[CH2:15][OH:16]>>[Cl:30][C:27]1[CH:28]=[CH:29][C:24]([O:23][CH:21]2[CH2:20][N:19]([CH2:18][CH2:17][C@H:14]([NH:11][C:9]([NH:8][C:6]3[S:7][C:3]([CH2:1][CH3:2])=[N:4][N:5]=3)=[O:10])[CH2:15][OH:16])[CH2:22]2)=[CH:25][C:26]=1[F:31]

Participants

3

Reactant 2

HCID 12256156HCID 12256156, compoundHCID 69410993HCID 69410993, compound

Product 1

HCID 69846752HCID 69846752, compound

Procedure

This compound is prepared analogously to 1-{(S)-3-[3-(4-chloro-phenoxy)-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(5-ethyl-[1,3,4-thiadiazol-2-yl)-urea in Example 99 except using (S)-2-amino-4-[3-(4-chloro-3-fluoro-phenoxy)-azetidin-1-yl]-butan-1-ol hydrochloride in place of (S)-2-amino-4-[3-(4-chloro-phenoxy)-azetidin-1-yl]-butan-1-ol hydrochloride.

Sources & evidence

ORD record
ord-d5df184325474cb595eba9279fb66807
Source dataset
uspto-grants-2007_10
Patent number
US07288537B2

Reaction notes

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