1-{(S)-3-[3-(4-Chloro-phenoxy)-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(5-ethyl-[1,3,4]-thiadiazol-2-yl)-urea → 1-{(S)-3-[3-phenoxy-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(5-ethyl-[1,3,4]thiadiazol-2-yl)-urea

HRID 1182148Notes

Reaction equation

HRID 1182148 reaction equation
Cl[C:2]1[CH:28]=[CH:27][C:5]([O:6][CH:7]2[CH2:10][N:9]([CH2:11][CH2:12][C@H:13]([NH:16][C:17]([NH:19][C:20]3[S:21][C:22]([CH2:25][CH3:26])=[N:23][N:24]=3)=[O:18])[CH2:14][OH:15])[CH2:8]2)=[CH:4][CH:3]=1.Cl.N[C@@H](CCN1CC(OC2C=CC=CC=2)C1)CO>>[O:6]([CH:7]1[CH2:10][N:9]([CH2:11][CH2:12][C@H:13]([NH:16][C:17]([NH:19][C:20]2[S:21][C:22]([CH2:25][CH3:26])=[N:23][N:24]=2)=[O:18])[CH2:14][OH:15])[CH2:8]1)[C:5]1[CH:27]=[CH:28][CH:2]=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 102380831-{(S)-3-[3-(4-Chloro-phenoxy)-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(5-ethyl-[1,3,4]-thiadiazol-2-yl)-ureaHCID 69409328(S)-2-amino-4-[3-phenoxy-azetidin-1-yl]-butan-1-ol hydrochloride

Product 1

HCID 698474941-{(S)-3-[3-phenoxy-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(5-ethyl-[1,3,4]thiadiazol-2-yl)-urea

Procedure

This compound is prepared analogously to 1-{(S)-3-[3-(4-chloro-phenoxy)-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(5-ethyl-[1,3,4]-thiadiazol-2-yl)-urea in Example 99 except using (S)-2-amino-4-[3-phenoxy-azetidin-1-yl]-butan-1-ol hydrochloride in place of (S)-2-amino-4-[3-(4-chloro-phenoxy)-azetidin-1-yl]-butan-1-ol hydrochloride.

Sources & evidence

ORD record
ord-2491413a8ba64076813259a4c5811f31
Source dataset
uspto-grants-2007_10
Patent number
US07288537B2

Reaction notes

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