2-Thiopheneboronic acid → HCID 69354355, compound

Participants

Reaction Steps

2-{[(5-bromo-1H-indol-3-yl)acetyl]amino}-4-methylbenzoic acid (product of example 6, 48 mg), thiophene-2-boronic acid (17 mg), tetrakis(triphenylphosphine)palladium(0) (12 mg) was heated in a mixture of 2M sodium carbonate solution (0.5 ml) and dimethoxyethane (0.5 ml) for 18 h at 80° C. The mixture was concentrated and diluted with DCM, then washed with 2N HCl for 1 hr. The solvent was reduced and the residue purified by mass-directed automated HPLC to give the title compound (2 mg). MH+391.

Provenance & Evidence