HuagongsheHuagongshe Chemistry Print Report · For research reference only
Heptane → 4-(2-Methoxypyrimidin-5-yl)glutaric anhydride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Heptane | HCID 8900 | — |
| Reactant | Trifluoroacetic anhydride | HCID 9845 | — |
| Reactant | 3-(2-methoxy-5-pyrimidinyl)Pentanedioic acid | HCID 11276493 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(2-Methoxypyrimidin-5-yl)glutaric anhydride | HCID 86606267 | 94% |
Reaction Steps
4-Carboxy-3-(2-methoxypyrimidin-5-yl)butanoic acid (11.5 kg) was treated with trifluoroacetic anhydride (12.1 kg) in THF (58 L) at 50-55° C. for several hours. Slow addition of heptane (195 L) followed by cooling to ambient temperature resulted in the crystallization of the title compound; 94% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07288655B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-a7b321e4eb9942c587e4c2540fe21264 |
| Source note | uspto-grants-2007_10 |