Hydrochloric Acid → 5-[2-[(Cyclohexyloxy)methyl]phenyl]-2-thiazolamine

Participants

Reaction Conditions

Reaction Steps

75 ml of an aqueous hydrochloric acid solution (1 M) are added to 11 g of 5-{-2-[(cyclohexyloxy)methyl]phenyl}-N-(diphenylmethylene)-1,3-thiazol-2-amine, obtained in step 1.4, in solution in 150 ml of methanol, and the mixture is stirred for 18 hours at 20° C. The mixture is evaporated to dryness, the residue is taken up in diethyl ether and washed with an aqueous sodium hydroxide solution (0.5 M). The organic phase is dried over anhydrous sodium sulfate and concentrated. The residue is chromatographed on a silica gel column, eluting with a dichloromethane/methanol 98/2 (v/v) mixture, to give 5.3 g of a beige-colored solid. m.p.=102° C.

Provenance & Evidence