反应详情

2 ml of sulfuric acid at 95% by mass are added to 2 g of 3,5-difluoromandelic acid in solution in 25 ml of methanol, and the mixture is kept under reflux for 6 hours. The medium is concentrated, the residue is taken up in ethyl acetate and washed with a sodium hydroxide solution (0.1 N). The organic phase is dried over anhydrous sodium sulfate and 2 g of oil are obtained.

1. temperatureunder reflux for 6 hours
2. concentrationThe medium is concentrated
3. washwashed with a sodium hydroxide solution (0.1 N)
4. dry with materialThe organic phase is dried over anhydrous sodium sulfate and 2 g of oil
5. customare obtained