反应详情

33 mL of thionyl chloride was added dropwise to a mixture of 50.3 g of 1-naphthylglycine (racemic modification) and 200 mL of methanol (dehydrated) at an inner temperature of 35° C. over 1 hour and the mixture was stirred at the same temperature for 3 hours to effect reaction. The reaction mixture was concentrated and the concentrated residue obtained was mixed with 200 mL of diethyl ether. Then, the crystals produced were isolated by filtration and washed with 50 mL of diethyl ether. The crystals isolated by filtration were dried at an inner temperature of 50° C. under reduced pressure to obtain 61.9 g of ochre 1-naphthylglycine methyl ester hydrochloride (yield: 98%).

1. customreaction
2. concentrationThe reaction mixture was concentrated
3. customthe concentrated residue obtained
4. customThen, the crystals produced
5. customwere isolated by filtration
6. washwashed with 50 mL of diethyl ether
7. customThe crystals isolated by filtration
8. customwere dried at an inner temperature of 50° C. under reduced pressure