2-Aminobenzenesulfonamide → HCID 69507448, compound

HRID 1182442Notes

Reaction equation

HRID 1182442 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:23])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([O:18]C)=[C:14]([CH:20]([CH3:22])[CH3:21])[CH:13]=1)[C:5](O)=[O:6].[NH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[S:31]([NH2:34])(=[O:33])=[O:32]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:23])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[C:14]([CH:20]([CH3:21])[CH3:22])[CH:13]=1)[C:5]([C:30]1[C:25]([NH2:24])=[C:26]([S:31]([NH2:34])(=[O:33])=[O:32])[CH:27]=[CH:28][CH:29]=1)=[O:6]

Participants

3

Reactant 2

HCID 728942-AminobenzenesulfonamideHCID 11015728HCID 11015728, compound

Product 1

HCID 69507448HCID 69507448, compoundYield 54%

Procedure

3,5-Dibromo-4-(4-methoxy-3-isopropylphenoxy)benzoic acid (0.035 mmol) was coupled with 2-aminobenzenesulphonamide (0.175 mmol) using the method described in Example 58. Purification on HPLC of the residue gave 11 mg (54%) of the title compound.

Workup

  1. customPurification on HPLC of the residue

Sources & evidence

ORD record
ord-9af6eb030fc94c24b2ebdc89288d9ea6
Source dataset
uspto-grants-2007_10
Patent number
US07288571B2

Reaction notes

Loading…