2-Methylbenzenesulfonamide → HCID 69507610, compound

HRID 1182443Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:23])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([O:18]C)=[C:14]([CH:20]([CH3:22])[CH3:21])[CH:13]=1)[C:5](O)=[O:6].[C:24]1([CH3:34])[C:25]([S:30]([NH2:33])(=[O:32])=[O:31])=[CH:26][CH:27]=[CH:28][CH:29]=1>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:23])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[C:14]([CH:20]([CH3:22])[CH3:21])[CH:13]=1)[C:5]([C:26]1[CH:27]=[CH:28][CH:29]=[C:24]([CH3:34])[C:25]=1[S:30]([NH2:33])(=[O:32])=[O:31])=[O:6]

Participants

Reactant 2

HCID 69242-Methylbenzenesulfonamide

HCID 11015728HCID 11015728, compound

Product 1

HCID 69507610HCID 69507610, compoundYield 74%

Procedure

3,5-Dibromo-4-(4-methoxy-3-isopropylphenoxy)benzoic acid (0.035 mmol) was coupled with 2-toluenesulphonamide (0.175 mmol) using the method described in Example 58. Purification on HPLC of the residue gave 15 mg (74%) of the title compound.

Workup

customPurification on HPLC of the residue

Sources & evidence

ORD record: ord-e34c0cd1e36242d48ed491f78926c07f
Source dataset: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07288571B2

Reaction notes

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