4-(2-Aminoethyl)benzenesulfonamide → HCID 86602262, compound

HRID 1182444Notes

Reaction equation

HRID 1182444 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:23])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([O:18]C)=[C:14]([CH:20]([CH3:22])[CH3:21])[CH:13]=1)[C:5]([OH:7])=O.[NH2:24][CH2:25][CH2:26][C:27]1[CH:32]=[CH:31][C:30]([S:33]([NH2:36])(=[O:35])=[O:34])=[CH:29][CH:28]=1>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:23])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[C:14]([CH:20]([CH3:22])[CH3:21])[CH:13]=1)[C:5]([C:29]1[CH:28]=[C:27]([CH2:26][CH2:25][NH2:24])[CH:32]=[CH:31][C:30]=1[S:33]([NH2:36])(=[O:35])=[O:34])=[O:7]

Participants

3

Reactant 2

HCID 1696824-(2-Aminoethyl)benzenesulfonamideHCID 11015728HCID 11015728, compound

Product 1

HCID 86602262HCID 86602262, compoundYield 47%

Procedure

3,5-Dibromo-4-(4-methoxy-3-isopropylphenoxy)benzoic acid (0.035 mmol) was coupled with 4-(2-aminoethyl)benzenesulphonamide (0.175 mmol) using the method described in Example 58. Purification on HPLC of the residue gave 10 mg (47%) of the title compound.

Workup

  1. customPurification on HPLC of the residue

Sources & evidence

ORD record
ord-2cb823d022384eadb4335ded651e291c
Source dataset
uspto-grants-2007_10
Patent number
US07288571B2

Reaction notes

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