Benzenesulfonamide, 3-nitro- → HCID 69507450, compound

HRID 1182445Notes

Reaction equation

HRID 1182445 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:23])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([O:18]C)=[C:14]([CH:20]([CH3:22])[CH3:21])[CH:13]=1)[C:5]([OH:7])=O.[N+:24]([C:27]1[CH:28]=[C:29]([S:33]([NH2:36])(=[O:35])=[O:34])[CH:30]=[CH:31][CH:32]=1)([O-:26])=[O:25]>>[Br:23][C:9]1[CH:8]=[C:4]([CH:3]=[C:2]([Br:1])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[C:14]([CH:20]([CH3:22])[CH3:21])[CH:13]=1)[C:5]([C:28]1[C:27]([N+:24]([O-:26])=[O:25])=[CH:32][CH:31]=[CH:30][C:29]=1[S:33]([NH2:36])(=[O:34])=[O:35])=[O:7]

Participants

3

Reactant 2

HCID 67138Benzenesulfonamide, 3-nitro-HCID 11015728HCID 11015728, compound

Product 1

HCID 69507450HCID 69507450, compoundYield 33%

Procedure

3,5-Dibromo-4-(4-methoxy-3-isopropylphenoxy)benzoic acid (0.035 mmol) was coupled with 3-nitrobenzenesulphonamide (0.175 mmol) using the method described in Example 58. Purification on HPLC of the residue gave 7 mg (33%) of the title compound.

Workup

  1. customPurification on HPLC of the residue

Sources & evidence

ORD record
ord-044d4a26893a4a39948437824c7f87a3
Source dataset
uspto-grants-2007_10
Patent number
US07288571B2

Reaction notes

Loading…