Hydroxyamine hydrochloride → HCID 11001628, compound

Participants

Reaction Steps

Following the procedure described in Example 14, step 3, but substituting carboxylic acid 50c for 37 and using 1.1 equivalent of NH2OH.HCl and triethylamine each, the title compound was obtained as light yellow solid in 35% yield: 1H NMR (300 MHz, CD3OD/CDCl3=5/1) δ 8.07 (d, J=8.4 Hz, 2H), 7.74 (d, J=8.4 Hz, 2H), 3.02 (t, J=7.5 Hz, 2H), 2.12 (t, J=7.5 Hz, 2H), 1.75 (m, 2H) 1.65 (m, 2H), 1.40 (m, 4H); 13C NMR (75.4 MHz, CD3OD/CDCl3=5/1) δ 23.57, 25.03, 28.51, 28.59, 32.50, 38.50, 123.37(q, JCF=273 Hz),125.43 (q, JCF=3.7 Hz), 128.18, 134.09 (q, JCF=32.6 Hz), 139.32, 171.15, 199.93.

Provenance & Evidence