Hydroxyamine hydrochloride → HCID 23072368, compound

Participants

Reaction Steps

Following the procedure described in Example 14, step 3, but substituting carboxylic acid 50j for 37 and using 1.1 equivalent of NH2OH.HCl and triethylamine each, the title compound was obtained as light yellow solid in 33% yield: 1H NMR (300 MHz, CD3OD/CDCl3=5/1) δ 8.09 (br s, 1H), 7.46 (m, 1H), 6.75 (m, 1H), 2.76 (t, J=7.5 Hz, 2H), 2.10 (t, J=7.5 Hz, 2H), 1.60-1.72 (m, 4H), 1.36 (m, 4H); 13C NMR (75.4 MHz, CD3OD/CDCl3=5/1) δ 23.90, 24.99, 28.45(2), 32.48, 39.98, 108.19, 127.37, 144.15, 147.43, 171.08, 196.21.

Provenance & Evidence