O-Phenylenediamine → HCID 58982145, compound

Participants

Reaction Steps

Following the procedure described in Example 22, but substituting carboxylic acid 50h for carboxylic acid 50g and 2-aminobenzylamine for 1,2-phenylenediamine respectively, the title compound 75 was obtained in 32% yield. 1H NMR (300 MHz, CDCl3): δ 8.02 (d, J=8.4 Hz, 2H), 7.71-7.61 (m, 4H), 7.37-7.51 (m, 3H), 7.12-7.01 (m, 2H), 6.70-6.62 (m, 2H), 5.76 (br s, 1H), 4.38 (d, J=6.3 Hz, 2H), 2.97 (t, J=7.5 Hz, 2H), 2.19 (t, J=7.5 Hz, 2H), 1.80-1.58 (m, 4H), 1.45-1.32 (m, 4H).

Provenance & Evidence