HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 86632631, compound → tert-Butyl (2-amino-3-fluorophenyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 86632631 | HCID 86632631 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | HCID 178418361 | HCID 178418361 | — |
| Product | tert-Butyl (2-amino-3-fluorophenyl)carbamate | HCID 56973654 | 66% |
Reaction Steps
To a solution of the N-tert-Butyloxycarbonyl-3-fluoro-2-nitro aniline (950 mg, 2.5 mmol) in MeOH was added catalytic amount of Raney Nickel in water, hydrogen was applied at 40 psi and the mixture was stirred overnight. The mixture was filtered over Celite and the solvent was evaporated to give the desired product in 66% yield (550 mg). MS (ESI)=226 (MH+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07288567B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-f6afd4ba0df94dd491a52fb0fc044975 |
| Source note | uspto-grants-2007_10 |