HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl (3-methoxy-2-nitrophenyl)carbamate → N-tert-Butyloxycarbonyl-3-methoxy-2-amino Aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl (3-methoxy-2-nitrophenyl)carbamate | HCID 10587951 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | HCID 178418361 | HCID 178418361 | — |
| Product | N-tert-Butyloxycarbonyl-3-methoxy-2-amino Aniline | HCID 10799950 | 55% |
Reaction Steps
To a solution of the N-tert-Butyloxycarbonyl-3-methoxy-2-nitro aniline (4 mmol) in MeOH was added catalytic amount of Raney Nickel in water, hydrogen was applied at 40 psi and the mixture was stirred overnight. The mixture was filtered over Celite and the solvent was evaporated to give the desired product in 55% yield. MS (ESI)=239 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07288567B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-7b7fa9d0503d4a919c5167dd4a865465 |
| Source note | uspto-grants-2007_10 |