Benzoyl chloride → HCID 58982159, compound

Participants

Reaction Steps

Following the procedure described in Example 18, step 2, 3, but substituting 2-cyclohexylcarbonyl chloride for benzoyl chloride, and then the resulting carboxylic acid was substituted for 37 in Example 14, step 3, using 1.1 equivalent of NH2OH.HCl and triethylamine each, to afford the title compound 102 obtained in 38% yield. 1H NMR (300 MHz, CDCl3): δ 2.45 (t, J=6.9 Hz, 2H), 2.36 (m, 2H), 2.10 (m, 2H), 1.80-1.25 (m, 17H). 13C NMR (75 MHz, 20% CD3OD in CDCl3): δ 23.13, 25.00, 25.35, 25.53, 28.22, 28.50, 28.51, 32.47, 40.27, 50.61, 177.11, 215.62.

Provenance & Evidence