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HRID1182554

反应详情

EQUATION

反应方程式

HRID 1182554 的结构方程式

REACTANTS

反应物

3
结构：CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HCID9886157

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

C10H15F6N6OP

结构：O=C(O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12
HCID16090778

未命名化合物

结构：Cl.N[C@@H](c1ccc(F)cc1F)C(F)(F)F
HCID86596675

未命名化合物

PRODUCTS

生成物

1
结构：O=C(N[C@@H](c1ccc(F)cc1F)C(F)(F)F)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12
HCID11272921

未命名化合物

PROCEDURE

实验过程

(S)-4-Chloro-N-[1-(2,4-difluorophenyl)-2,2,2-trifluoroethyl-1]-2-(quinoxaline-5-sulfonylamino)-benzamide. The title compound was prepared from the HATU-mediated coupling of 4-chloro-2-(quinoxaline-5-sulfonylamino)benzoic acid (EXAMPLE 3, Step B) and (S)-1-(2,4-difluorophenyl)-2,2,2-trifluoroethylamine hydrochloride and purified as described in EXAMPLE 1, Step K. MS (ESI): mass calculated for C23H14ClF5N4O3S, 556.0; m/z found, 555/557 [M−H]−. HPLC (reverse phase): RT=9.98 min. 1H NMR (400 MHz, CDCl3): 11.07 (s, 1H), 8.84-8.83 (m, 2H), 8.56 (dd, J=7.4, 1.4 Hz, 1H), 8.31 (dd, J=7.4, 1.4 Hz, 1H), 7.87 (dd, J=8.4, 7.4 Hz, 1H), 7.81 (d, J=2.0 Hz, 1H), 7.43-7.37 (m, 1H), 7.30 (d, J=8.5 Hz, 1H), 7.03-6.93 (m, 3H), 6.81-6.79 (m, 1H), 6.08-6.00 (m, 1H).

WORKUP

后处理

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