反应详情

30.0 mg (1.38 mmol) of 3-oxo-N-(3-phenyl-2-propen-1-yl) butylamide and 194 mg (1.38 mmol) of 3-chlorobenzaldehyde were dissolved in 20 ml of 2-propanol. 4.14 mg (0.0690 mmol) of piperidine and 5.67 mg (0.0690 mmol) of acetic acid were added thereto and-stirred at room temperature for 2 days. After the solvent was evaporated under reduced pressure, ethyl acetate was added to the reaction mixture. After washing with 1 N hydrochloric acid and then with saturated aqueous sodium hydrogencarbonate solution, the organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was purified by the silica gel chromatography (hexane/ethyl acetate=10/1) to obtain the title compound.

1. customAfter the solvent was evaporated under reduced pressure, ethyl acetate
2. additionwas added to the reaction mixture
3. washAfter washing with 1 N hydrochloric acid
4. dry with materialwith saturated aqueous sodium hydrogencarbonate solution, the organic layer was dried over anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure
6. customThe residue was purified by the silica gel chromatography (hexane/ethyl acetate=10/1)