Hydrochloric Acid → HCID 9870622, compound

Participants

Reaction Steps

275 mg (0.500 mmol) of 4-(3-chlorophenyl)-2,6-dimethyl-5-(3,3-diphenylpropylcarbamoyl)-1,4-dihydropyridine-3-carboxylic acid 2-cyanoethyl ester was dissolved in 10 ml of methanol. 1 ml of 1 N aqueous sodium hydroxide solution was added and stirred at room temperature for 7.5 hours. After adding 2 N hydrochloric acid, methanol was evaporated under reduced pressure. Water was added to the residue, and precipitates thus formed were taken by the filtration, then washed with water and hexane/ethyl acetate (3/1) and dried under reduced pressure to obtain the title compound.

Provenance & Evidence