Acetone → HCID 86760568, compound

HRID 1182581Notes

Reaction equation

HRID 1182581 reaction equation
C[C:2](C)=[O:3].[Cl:5][C:6]1[CH:7]=[C:8]([CH:12]2[C:17]([C:18](=[O:35])[NH:19][CH2:20][CH2:21][CH:22]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[C:16]([CH3:36])[NH:15][C:14]([CH3:37])=[C:13]2C(O)=O)[CH:9]=[CH:10][CH:11]=1.[N+]([O-])([O-])=[O:42].[NH4+].[Ce]>O>[Cl:5][C:6]1[CH:7]=[C:8]([C:12]2[C:17]([C:18](=[O:35])[NH:19][CH2:20][CH2:21][CH:22]([C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[C:16]([CH3:36])[NH:15][C:14]([CH3:37])([C:2]([OH:3])=[O:42])[CH:13]=2)[CH:9]=[CH:10][CH:11]=1

Participants

5

Reactant 3

HCID 180AcetoneHCID 9870622HCID 9870622, compoundHCID 57418452Ammonium cerium-nitrate

Product 1

HCID 86760568HCID 86760568, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

2 ml of acetone was added to 57.3 mg (0.110 mmol) of 4-(3-chlorophenyl)-2,6-dimethyl-5-(3,3-diphenylpropylcarbamoyl)-1,4-dihydropyridine-3-carboxylic acid. 178 mg (0.320 mmol) of cerium ammonium nitrate suspended in 1 ml of water was added and stirred at room temperature for 2.5 hours. After adding water and extracting with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain the title compound.

Workup

  1. additionwas added
  2. extractionextracting with ethyl acetate
  3. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-b93316479fae43b2be7da8ceb7b1f91e
Source dataset
uspto-grants-2007_10
Patent number
US07288544B2

Reaction notes

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