反应详情

温度

80 °C

2.09 g (6.43 mmol) of 4-(3-chlorophenyl)-6-methyl-2-(methylthio)-1,4-dihydropyrimidine-5-carboxylic acid ethylester was dissolved in 30 ml of chloroform. 8.39 g (96.5 mmol) of manganese dioxide was added at room temperature and stirred at 80° C. for 2 hours. After filtration of insoluble matters, the obtained filtrate was concentrated under reduced pressure. The residue was purified by the silica gel chromatography (hexane/ethyl acetate=10/1) to obtain the title compound.

1. filtrationAfter filtration of insoluble matters
2. concentrationthe obtained filtrate was concentrated under reduced pressure
3. customThe residue was purified by the silica gel chromatography (hexane/ethyl acetate=10/1)