Acetone → HCID 10145745, compound

HRID 1182622Notes

Reaction equation

HRID 1182622 reaction equation
CC(C)=O.[CH:5]1[C:15]2[CH:14]=[CH:13][C:12]3[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=3[C:10](=[C:20]3[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][CH2:28][O:29][C:30]([C:32]4[CH:37]([C:38]5[CH:43]=[CH:42][CH:41]=[C:40]([Cl:44])[CH:39]=5)[C:36]([C:45]([OH:47])=[O:46])=[C:35]([CH3:48])[NH:34][C:33]=4[CH3:49])=[O:31])[CH2:22][CH2:21]3)[C:9]=2[CH:8]=[CH:7][CH:6]=1.[N+]([O-])([O-])=O.[NH4+].[Ce]>O>[Cl:44][C:40]1[CH:39]=[C:38]([C:37]2[C:36]([C:45]([OH:47])=[O:46])=[C:35]([CH3:48])[N:34]=[C:33]([CH3:49])[C:32]=2[C:30]([O:29][CH2:28][CH2:27][CH2:26][N:23]2[CH2:22][CH2:21][C:20](=[C:10]3[C:9]4[CH:8]=[CH:7][CH:6]=[CH:5][C:15]=4[CH:14]=[CH:13][C:12]4[CH:16]=[CH:17][CH:18]=[CH:19][C:11]3=4)[CH2:25][CH2:24]2)=[O:31])[CH:43]=[CH:42][CH:41]=1

Participants

5

Reactant 3

HCID 180AcetoneHCID 57418452Ammonium cerium-nitrateHCID 86590787HCID 86590787, compound

Product 1

HCID 10145745HCID 10145745, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5 ml of acetone was added to 132 mg (0.21 mmol) of 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid mono (3-(4-(5H-dibenzo[a,d] cyclohepten-5-ylidene) piperidine-1-yl) propan-1-yl) ester. 233 mg (0.43 mmol) of cerium ammonium nitrate suspended in 5 ml of water was added and stirred at room temperature for 2 hours. After acetone was evaporated under reduced pressure, ethyl acetate was added and precipitates were taken by the filtration and dried under reduced pressure to obtain the title compound.

Workup

  1. additionwas added
  2. customAfter acetone was evaporated under reduced pressure, ethyl acetate
  3. additionwas added
  4. customprecipitates
  5. filtrationwere taken by the filtration
  6. customdried under reduced pressure

Sources & evidence

ORD record
ord-27d90bc443fa4ee9805dbd637e8d5a93
Source dataset
uspto-grants-2007_10
Patent number
US07288544B2

Reaction notes

Loading…