HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 49763920, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Phenyl-4-carboxythiazole | HCID 138928 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 22017388 | HCID 22017388 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 49763920 | HCID 49763920 | 49% |
Reaction Steps
To a solution of 2-phenyl-1,3-thiazole-4-carboxylic acid (5.1 mg) and DIPEA (3 eq) in DMF (0.4 mL) was added TBTU (1.2 eq) in DMF (0.2 mL). Then, a solution of 4-(2-amino-acetyl)-piperazine-1-carboxylic acid ethyl ester (5.4 mg, prepared as described in WO2006114774) in DMF (0.2 mL) was added. After stirring overnight at RT, the reaction mixture was directly purified by preparative HPLC (IV) to give 4.9 mg of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08664203B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-562e7c56b4b346a3940ce6373b743d87 |
| Source note | uspto-grants-2014_03 |