HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-((S)-2-Amino-4-carboxy-butyryl)-piperazine-1-carboxylic acid ethyl ester trifluoroacetate salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | ethyl 4-[(2S)-2-amino-5-tert-butoxy-5-oxopentanoyl]piperazine-1-carboxylate | HCID 66651766 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-((S)-2-Amino-4-carboxy-butyryl)-piperazine-1-carboxylic acid ethyl ester trifluoroacetate salt | HCID 66771955 | — |
Reaction Steps
To a solution of 4-((S)-2-amino-4-tert-butoxycarbonyl-butyryl)-piperazine-1-carboxylic acid ethyl ester (0.8 g, prepared as described in WO2006114774) in CH2Cl2 (15 mL) was added TFA (15 mL) and the reaction mixture stirred for 2 h at RT. The solution was evaporated to dryness to give 0.9 g of the desired product as clear oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08664203B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-02d982387bfb4925a35fe8e398cd0776 |
| Source note | uspto-grants-2014_03 |