1-Piperazinecarboxylic acid, ethyl ester → HCID 66770437, compound

HRID 1182674Notes

Reaction equation

HRID 1182674 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])[CH3:2].[NH:12]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[C@H:13]([C:22](O)=[O:23])[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([I:21])=[CH:17][CH:16]=1>>[CH2:1]([O:3][C:4]([N:6]1[CH2:7][CH2:8][N:9]([C:22](=[O:23])[C@@H:13]([NH:12][C:25]([O:27][C:28]([CH3:30])([CH3:29])[CH3:31])=[O:26])[CH2:14][C:15]2[CH:16]=[CH:17][C:18]([I:21])=[CH:19][CH:20]=2)[CH2:10][CH2:11]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 84311-Piperazinecarboxylic acid, ethyl esterHCID 2755956(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-(4-iodophenyl)propanoic acid

Product 1

HCID 66770437HCID 66770437, compound

Procedure

This compound was prepared using a method analogous to that of Example 8, step 8.3, piperazine-1-carboxylic acid ethyl ester replacing piperazine-1-carboxylic acid butyl ester and Boc-Phe(4-I)-OH replacing intermediate 8.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-b18ea077512946b7a1675ba41bd07ef0
Source dataset
uspto-grants-2014_03
Patent number
US08664203B2

Reaction notes

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