Dibutyltin oxide → HCID 178441717, compound

Participants

Reaction Conditions

Reaction Steps

Process 3: To the toluene (3 mL) solution of 4′-{[4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl]methyl}biphenyl-2-carbonitrile (335 mg, 0.77 mmol), trimethylsilylazide (2.64 g, 22.9 mmol) and dibutyltin oxide (96 mg, 0.386 mmol) were added, and stirred at 80° C. for 24 hrs under argon atmosphere. The reaction solvent was distilled off and the resulting residues were separated and purified by silica gel column chromatography (chloroform:methanol=100:1) to obtain the target compound (224 mg, 61%) as a pale yellow amorphous.

Provenance & Evidence