HCID 58553807, compound → HCID 58553813, compound

Participants

Reaction Steps

To the methanol (10 mL) solution of 4′-{[1-[5-(benzyloxy)pyrimidin-2-yl]-4-butyl-2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]methyl}biphenyl-2-carbonitrile (235 mg, 0.434 mmol), 10% Pd—C (containing 50% moisture, 120 mg) was added for hydrogenation. After stirring at room temperature for 1 hr, the reaction mixture was filtered through a pad of celite and washed with methanol. The filtrate was distilled off and the resulting residues were subjected to silica gel column chromatography (chloroform:methanol=10:1) to obtain 4′-{[4-butyl-1-(5-hydroxypyrimidin-2-yl)-2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]methyl}biphenyl-2-carbonitrile.

Provenance & Evidence