Hydrochloric Acid → HCID 178441721, compound

Participants

Reaction Steps

To the ethanol (1 mL) solution of 5-{[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-6-butyl-3-{5-[4-(tert-butyldimethylsilyloxy)cyclohexyloxy]pyrimidin-2-yl}-2-methylpyrimidin-4 (3H)-one (38 mg, 0.054 mmol), conc. HCl (30 mg, 0.823 mmol) was added and stirred at room temperature for 1 hr. The reaction mixture was concentrated in vacuo, and the resulting residues were subjected to silica gel column chromatography (chloroform:methanol=5:1) to obtain 5-{[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-6-butyl-3-[5-(4-hydroxycyclohexyloxy)pyrimidin-2-yl]-2-methylpyrimidin-4 (3H)-one.

Provenance & Evidence