Dichloromethane → HCID 178441720, compound

Participants

Reaction Steps

To the dichloromethane (0.5 mL) solution of 5-{[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-6-butyl-3-[5-(4-hydroxycyclohexyloxy)pyrimidin-2-yl]-2-methylpyrimidin-4 (3H)-one (10 mg, 0.017 mmol), Dess-Martin reagent (11 mg, 0.026 mmol) was added and stirred at room temperature for 1 hr. Dess-Martin reagent (11 mg, 0.026 mmol) was added, and further stirred at room temperature overnight. The reaction mixture was added water and extracted with chloroform. The organic layer was combined, washed with water and brine, dried over anhydrous sodium sulfate, and concentrated in vacuo. The resulting residues were subjected to silica gel column chromatography (chloroform:methanol=5:1) to obtain the target compound.

Provenance & Evidence