Acetic Acid → HCID 58664156, compound

Participants

Reaction Steps

The acetic acid (180 mL) solution of 3-oxobutan-2-yl furan-2-carboxylic acid (18.2 g, 100 mmol) and ammonium acetate (38.6 g, 500 mmol) was stirred for 5 hrs under heating reflux condition. The reaction mixture was added water and extracted with ethyl acetate. The organic layer was combined, washed with water and brine, dried over anhydrous sodium sulfate, and concentrated in vacuo. The resulting residues were subjected to silica gel column chromatography (hexane/ethyl acetate) to obtain 2-(furan-2-yl)-4,5-dimethyloxazole (6.4 g, 40%) as a pale yellow oil.

Provenance & Evidence