Lithium Hydroxide → HCID 178441725, compound

Participants

Reaction Conditions

Reaction Steps

To the mixture solution of tetrahydrofuran (2 mL) and water (2 mL) containing 2-{2-(5-{[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-4-butyl-2-methyl-6-oxopyrimidin-1 (6H)-yl)pyrimidin-5-yl oxy}ethyl acetate (22 mg, 0.038 mmol), lithium hydroxide (8 mg, 0.29 mmol) was added and stirred at 50° C. for 1 hr. The reaction mixture was added water and extracted with chloroform. The organic layer was combined, washed with water and brine, dried over anhydrous sodium sulfate, and concentrated in vacuo. The resulting residues were subjected to silica gel column chromatography (chloroform/methanol) to obtain the target compound (15 mg, 72%) as a white solid.

Provenance & Evidence