Pyridine → HCID 66706065, compound

Participants

Reaction Steps

Process 3: To the dichloromethane (1 mL) solution of the crude product of 4′-{{1-[5-(3-aminopropoxy)pyrimidin-2-yl]-4-butyl-2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl}methyl}biphenyl-2-carbonitrile (45 mg), pyridine (9.7 mg, 0.123 mmol) and acetyl chloride (8.3 mg, 0.106 mmol) were added and stirred at room temperature overnight. The reaction mixture was added water, and extracted with ethyl acetate. The organic layer was combined, washed with water and brine, and dried over anhydrous sodium sulfate. The solvent was distilled off to obtain N-{3-{2-{4-butyl-5-[(2′-cyanobiphenyl-4-yl)methyl]-2-methyl-6-oxopyrimidin-1 (6H)-yl}pyrimidin-5-yl oxy}propyl}acetamide (35 mg) as a crude product.

Provenance & Evidence