Potassium Phosphate, Tribasic → HCID 24853524, compound

Participants

Reaction Steps

70 mg (0.17 mmol) 7-bromo-4-ethoxy-9-methoxy-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole, 56 mg (0.26 mmol) 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline, 119 mg (0.51 mmol) K3PO4×H2O, 2.8 mg (6.8 μmol) S-Phos and 0.8 mg (3.4 μmol) Pd(OAc)2 in 6 ml dioxan were heated in a microwave oven to 120° C. for 1 h. Then, the solvent was removed and after LC (CH2Cl2:MeOH, 0-20%) 20 mg (24%) of the title substance was obtained. ESI-MS [m/z]: 419 [M+H]+

Provenance & Evidence