HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 24990556, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine | HCID 2734648 | — |
| Reactant | 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl | HCID 11269872 | — |
| Reactant | HCID 66863771 | HCID 66863771 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 24990556 | HCID 24990556 | — |
Reaction Steps
60 mg (0.15 mmol) 7-bromo-4-ethoxy-9-methoxy-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole (Example 1), 47 mg (0.23 mmol) 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, 61 mg (0.45 mmol) K2CO3, 2.4 mg (6.0 μmol) S-Phos and 0.7 mg (3.0 μmol) Pd(OAc)2 in 6 ml dioxan were heated in a microwave oven to 120° C. for 1 h. Thereafter, the solvent was removed and following LC (CH2Cl2:MeOH, 0-30%) 27 mg (45%) of the title substance was obtained. ESI-MS [m/z]: 405 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08664233B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-c3baba9e516949d19b2f91842eab3ec1 |
| Source note | uspto-grants-2014_03 |