Water → HCID 58118527, compound

Participants

Reaction Steps

1.3 g (5.1 mmol) 3-amino-5-bromo-1H-indole-2-carboxylic acid amide was suspended in 50 ml dioxan and, after the addition of 670 μl (5.5 mmol) diphosgene, refluxed for 2 h. Having cooled down to room temperature, 2 ml water was carefully added and thereafter the precipitate was sucked off. 1.4 g (94%) 8-bromo-1H-pyrimido[5,4-b]indole-2,4(3H,5H)-dione was obtained. ESI-MS [m/z]: 278, 280 [M−H]−

Provenance & Evidence